During a recent appearance on the podcast Ruthless, Kelly questioned why the actress had become a prominent advocate for MS, suggesting that Applegate’s public disclosure of her symptoms was performative. Kelly argued that the actress had leaned into the diagnosis to become a public face for the disease, only to later reveal the initial medical assessment was wrong. She characterized the situation as a deception, claiming the actress was now upset because she no longer held that specific platform.
Fans and observers quickly condemned the remarks as callous, noting that Applegate remains physically impaired and continues to face significant medical challenges. Critics pointed out that the actress still requires mobility aids and has expressed deep confusion and distress over her lack of a formal diagnosis. Neurologists, including Dr. Marwa Kaisey of Cedars-Sinai Medical Center, have noted that misdiagnoses for multiple sclerosis are common, as the condition relies on a complex list of criteria rather than a single definitive test. Applegate herself has expressed feelings of guilt, fearing she has let down the community of patients she sought to support, even as she continues to search for answers regarding her health.




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