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Seed Health Data Suggests Co-Biotics Reshape Microbiome Nutrient Pathways

Seed Health Data Suggests Co-Biotics Reshape Microbiome Nutrient Pathways

Microbiome science company Seed Health has unveiled preclinical data indicating that its specialized Co-Biotic formulations can trigger distinct microbial pathways to boost vitamin B3, short-chain fatty acids, and tryptophan availability. Presented at NUTRITION 2026, the findings challenge the traditional approach of designing supplements solely for human biology.

Researchers utilized an ex vivo gastrointestinal model equipped with SIFR technology to evaluate three products: DM-02 Daily Multivitamin, AM-02 Energy + Focus, and PM-02 Sleep + Restore. The results demonstrate that these supplements modulate microbial composition to enhance nutrient metabolism and gut-brain signaling, moving beyond the scope of conventional vitamins.

DM-02 showed a 10-fold increase in bioactive vitamin B3 compared to standard nicotinic acid, alongside a significant rise in short-chain fatty acids. Meanwhile, AM-02 targeted the gut-brain axis by increasing acetate and butyrate production by 12% and 20% respectively. The sleep-focused PM-02 formulation improved tryptophan availability by 48% and strengthened gut barrier function by 18% under stress. According to CEO Cathrin Bowtell, the data confirms that designing products for both the body and its microbiome can unlock new potential in consumer health, providing a mechanistic foundation for the Co-Biotic category.

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